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Dynamics of Atg5-Atg12-Atg16L1 Aggregation and Deaggregation.
Kharaziha P, Panaretakis T. Kharaziha P, et al. Methods Enzymol. 2017;587:247-255. doi: 10.1016/bs.mie.2016.09.059. Epub 2016 Dec 3. Methods Enzymol. 2017. PMID: 28253959
The interaction between Atg5-Atg12 complex and Atg16L1 is highly dynamic, induced upon activation of the autophagic process, and required for the recruitment of the At5-Atg12 complex to sites of autophagosome formation. ...In this chapter, we describe methods of mon …
The interaction between Atg5-Atg12 complex and Atg16L1 is highly dynamic, induced upon activation of the autophagic process, and requ …
The role of ATG16L2 in autophagy and disease.
Don Wai Luu L, Kaakoush NO, Castaño-Rodríguez N. Don Wai Luu L, et al. Autophagy. 2022 Nov;18(11):2537-2546. doi: 10.1080/15548627.2022.2042783. Epub 2022 Mar 3. Autophagy. 2022. PMID: 35239457 Free PMC article. Review.
Overexpression of ATG16L2 has been reported in various cancers including colorectal, gastric, and prostate carcinomas, whereas altered methylation of ATG16L2 has been associated with lung cancer formation and poorer response to therapy in leukemia. ...Here, we review curre …
Overexpression of ATG16L2 has been reported in various cancers including colorectal, gastric, and prostate carcinomas, whereas altere …
Microarray-based identification of differentially expressed genes associated with andrographolide derivatives-induced resistance in colon and prostate cancer cell lines.
Quah SY, Wong CC, Wong HC, Ho KL, Abdul Manan N, Deb PK, Sagineedu SR, Stanslas J. Quah SY, et al. Toxicol Appl Pharmacol. 2021 Aug 15;425:115605. doi: 10.1016/j.taap.2021.115605. Epub 2021 Jun 1. Toxicol Appl Pharmacol. 2021. PMID: 34087331
Andrographolide-derived SRJ09 and SRJ23 were reported to exhibit potent, selective inhibitory activities against colon and prostate cancer cells, respectively. In this study, previously developed resistant colon (HCT-116(rst09)) and prostate (PC-3(rst23)) cancer cel …
Andrographolide-derived SRJ09 and SRJ23 were reported to exhibit potent, selective inhibitory activities against colon and prostate c …
Combination of Arsenic trioxide and Everolimus (Rad001) synergistically induces both autophagy and apoptosis in prostate cancer cells.
Tai S, Xu L, Xu M, Zhang L, Zhang Y, Zhang K, Zhang L, Liang C. Tai S, et al. Oncotarget. 2017 Feb 14;8(7):11206-11218. doi: 10.18632/oncotarget.14493. Oncotarget. 2017. PMID: 28061438 Free PMC article.
The inhibitor of PI3K-AKT-mTOR pathway, such as Rad001, has not shown therapeutic efficacy as a single agent in prostate cancer. Arsenic trioxide induces the autophagic pathway in prostate cancer cells. ...This enhanced autophagic cell death is accompanied by increa …
The inhibitor of PI3K-AKT-mTOR pathway, such as Rad001, has not shown therapeutic efficacy as a single agent in prostate cancer. Arse …
Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway.
Kumar D, Shankar S, Srivastava RK. Kumar D, et al. Cancer Lett. 2014 Feb 28;343(2):179-89. doi: 10.1016/j.canlet.2013.10.003. Epub 2013 Oct 11. Cancer Lett. 2014. PMID: 24125861
However, the molecular mechanisms by which it induces autophagy in prostate CSCs have not been examined. The main objective of the paper was to examine the molecular mechanisms by which Rott induces autophagy in prostate CSCs. ...Rott induced the lipid modification …
However, the molecular mechanisms by which it induces autophagy in prostate CSCs have not been examined. The main objective of the pa …
CCT020312 exerts anti-prostate cancer effect by inducing G1 cell cycle arrest, apoptosis and autophagy through activation of PERK/eIF2alpha/ATF4/CHOP signaling.
Zhou D, Yin M, Kang B, Yu X, Zeng H, Chen B, Wang G, Song Y, Liu X, He Q, Wu Q, Zhang L, Wu L, Wu Y, Qu N, Li X, Zhou W. Zhou D, et al. Biochem Pharmacol. 2024 Mar;221:116038. doi: 10.1016/j.bcp.2024.116038. Epub 2024 Jan 28. Biochem Pharmacol. 2024. PMID: 38286211
CCT020312 treatment caused cell cycle arrest at G1 phase and increased the levels of cleaved-Caspase3, cleaved-PARP and Bax in prostate cancer C4-2 and LNCaP cells. Moreover, CCT020312 increased LC3II/I, Atg12-Atg5 and Beclin1 levels and induced autophagosome format …
CCT020312 treatment caused cell cycle arrest at G1 phase and increased the levels of cleaved-Caspase3, cleaved-PARP and Bax in prostate …
Autophagy is differentially induced in prostate cancer LNCaP, DU145 and PC-3 cells via distinct splicing profiles of ATG5.
Ouyang DY, Xu LH, He XH, Zhang YT, Zeng LH, Cai JY, Ren S. Ouyang DY, et al. Autophagy. 2013 Jan;9(1):20-32. doi: 10.4161/auto.22397. Epub 2012 Oct 17. Autophagy. 2013. PMID: 23075929 Free PMC article.
Transfection of the wild-type ATG5 gene into DU145 cells rescued the production of ATG5 and ATG12-ATG5 conjugates, resulting in formation of LC3-II conjugates and LC3 puncta. ...Collectively, these results indicated that VPA-induced autophagy in prostate cancer cell …
Transfection of the wild-type ATG5 gene into DU145 cells rescued the production of ATG5 and ATG12-ATG5 conjugates, resulting in forma …
Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells.
Tai S, Sun Y, Liu N, Ding B, Hsia E, Bhuta S, Thor RK, Damoiseaux R, Liang C, Huang J. Tai S, et al. Mol Cancer Ther. 2012 Jun;11(6):1320-31. doi: 10.1158/1535-7163.MCT-11-0954. Epub 2012 Apr 5. Mol Cancer Ther. 2012. PMID: 22491797 Free PMC article.
Through a high-throughput screen of 5,000 widely used small molecules, we identified compounds that can synergize with Rad001 to inhibit prostate cancer cells. One of the compounds, propachlor, synergizes with Rad001 to induce apoptosis of castration-resistant prostate …
Through a high-throughput screen of 5,000 widely used small molecules, we identified compounds that can synergize with Rad001 to inhibit …
Cell killing and radiosensitizing effects of atorvastatin in PC3 prostate cancer cells.
He Z, Mangala LS, Theriot CA, Rohde LH, Wu H, Zhang Y. He Z, et al. J Radiat Res. 2012;53(2):225-33. doi: 10.1269/jrr.11114. J Radiat Res. 2012. PMID: 22510595 Free article.
Inhibition of the autophagic process using small interfering RNAs (siRNA) targeting Atg7 and/or Atg12 significantly reduced radiosensitivity of PC3 cells. Statin also exhibited a significant apoptosis-inducing effect in PC3 cells, which can be partially suppressed by Atg7 …
Inhibition of the autophagic process using small interfering RNAs (siRNA) targeting Atg7 and/or Atg12 significantly reduced radiosens …
Photodynamic therapy induced cell death of hormone insensitive prostate cancer PC-3 cells with autophagic characteristics.
Xu DD, Lam HM, Hoeven R, Xu CB, Leung AW, Cho WC. Xu DD, et al. Photodiagnosis Photodyn Ther. 2013 Sep;10(3):278-87. doi: 10.1016/j.pdpdt.2013.01.002. Epub 2013 Apr 6. Photodiagnosis Photodyn Ther. 2013. PMID: 23993854
The evidence of PDT efficacy for androgen-refractory prostate cancer will be especially meaningful for the patients resistant to hormone therapy. ...CONCLUSIONS: PhA-mediated PDT induced significant autophagy in hormone-refractory prostate cancer PC-3 cells....
The evidence of PDT efficacy for androgen-refractory prostate cancer will be especially meaningful for the patients resistant to horm …
12 results